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Equine Science Solutions

The Science behind Our Equine formulas and Formulas

This unique technology separates us from all other products and is the new gold standard for providing optimum health.

The PRO Formulas, PLUS Formulas and Extras are created from Nobel Prize Winning Science about Nitric Oxide. Nitric Oxide (NO) increases blood flow to damaged tissues, organs and tissues under high demand or stress. Our products are designed to efficiently and safely promote Nitric Oxide production for up to 6 hours via Nitric Oxide precursors (arginine and other co-factors), flavonoids regulators, Nitric Oxide synthases enhancing elements and network antioxidants (to minimize free radical related oxidative stress).

Keep your horse healthy and powerful

Please see the articles below for a better understanding of how Nitric Oxide triggers the healing in horses and can help to resolve health issues: Healthy Horses


Scientific Research on Nitric Oxide:

There are three forms of Nitric Oxide:
• NO1 - Produced by the body
• NO2 - Inducible
• NO3 - A poisonous gas

Most of the research before 2000 was done with NO3 because it was inexpensive and provided fast results. The research presented here uses NO2. Our products are based on ADNO therapy - Arginine Derived Nitric Oxide, which uses Nitric Oxide per-curser to allow the body to produce its own Nitric Oxide via Nitric Oxide Synthases which converts Arginine to Nitric Oxide. ADNO is a multifaceted molecular marvel, which was only recently discovered by researchers.

There are 3 distinct Nitric Oxide Synthases (NOS) in two categories:

Constitutive - endothelial and neuronal NOS.
These synthases are calcium dependent and can be driven by hormones in the body such as estrogen and progesterone (i.e. pregnancy).
Inducible - inducible NOS.
This synthase is not calcium dependent and is driven when the immune system is attached such in the case of an infection or injury.

Three NO Synthases:
Endothelial - known as eNOS. Signals the endothelial tissue of blood vessels to relax and dilate. (Constitutive)
Neuronal - known as nNOS. A neurotransmitter and communicator between brain cells and can also signal eNOS. (Constitutive)
Inducible - known as iNOS. Our immune system synthase. (Inducible)

As you research the uses of NO please be sure to identify if the research was conducted with iNOS, nNOS, or eNOS. Equine Science Solution products only use endothelial NO and are ADNO formulated.

Healthy Horses

Nitric Oxide Articles:

1. Nitric Oxide - Menace to Marvel
A briefing document prepared for the Royal Society and Association of British Science Writers.
Research papers continue to flood the scientific journals with insights into the biological activity and potential clinical uses of nitric oxide (NO).
2. Nitric Oxide - Missed Biochemical Pathway
A new study by Duke University researchers provides more evidence that the nitric oxide (NO) system in the life of a cell plays a key role in disease, and the findings point to ways to improve treatment of illnesses such as heart disease and cancer.

Laminitis Research:

1. LSU Laminitis Research
Two equine researchers at the Louisiana State University (LSU) School of Veterinary Medicine recently received a USDA National Research Initiative Mechanisms of Disease Grant to study the cause of laminitis.
2. Grass Laminitis Research Paper
A Research of Nitric oxide donors as treatment for grass induced acute laminitis in ponies by Department of Animal and Plant Sciences, University of Sheffield, UK.

Nitric Oxide Nutraceutical PRO Formulas:

1. Nitro PRO Tech Sheet
While controversy exist about the causation of laminitis, there is little question as to the role of compromised laminar bloodflow in the pathophysiology and management of acute and chronic laminitis. (LSU press release). This has lead to efforts to improve laminar bloodflow via NO therapies .
2. Injury PRO Tech Sheet
Injury PRO promotes the production of Nitric Oxide is a bioidentical NO therapy engineered to deliver clinically proven restorative NO precursor amino acids, neutralizing network antioxidants, regulating flavonoid, vitamins, minerals, and whole herbs to the soft tissue injuries via endothelial Nitric Oxide Synthase (eNOS) mediated bloodflow.
3. Gastro PLUS PRO Research Study
Fifty-one Thoroughbred race horses in race training and competition were identified to have active gastric ulcers and were enrolled in a study to determine the effect of an arginine-derived nitric oxide (ADNO) supplement on gastric ulcer healing.
4. Equine Case Studies
Veterinarian diagnosis: Severe arthritis, old bowed tendons (both front legs) L. front inflamed due to improper bandaging, very poor front end conformation, over at the knees, contracted tendons.

Healthy Horses