Safe, Effective



Horse Health, Maintenance, & Performance

(888) 917-8565

Professional Grade Formulas For Your Horse

Horse Joints, Cartilage, Ligaments, Tendons and Synovial Fluids

The Science & Research Behind Treatment of Joints

Scientific Research on Nitric Oxide:

There are three forms of Nitric Oxide:
• NO1 - Produced by the body
•NO2 - Inducible
• NO3 - A poisonous gas

Most of the research before 2000 was done with NO3 because it was inexpensive and provided fast results. The research presented here uses NO2. Our products are based on ADNO therapy - Arginine Derived Nitric Oxide, which uses Nitric Oxide per-curser to allow the body to produce its own Nitric Oxide via Nitric Oxide Synthases which converts Arginine to Nitric Oxide. ADNO is a multifaceted molecular marvel, which was only recently discovered by researchers.

There are 3 distinct Nitric Oxide Synthases (NOS) in two categories:

Constitutive - endothelial and neuronal NOS
These synthases are calcium dependent and can be driven by hormones in the body such as estrogen and progesterone (i.e. pregnancy).

Horse Joints, Cartilage, Ligaments, Tendons and Synovial Fluids

Inducible - inducible NOS
This synthase is not calcium dependent and is driven when the immune system is attached such in the case of an infection or injury.

Three NO Synthases:
Endothelial - known as eNOS Signals the endothelial tissue of blood vessels to relax and dilate. (Constitutive)
Neuronal - known as nNOS A neurotransmitter and communicator between brain cells and can also signal eNOS. (Constitutive)
Inducible - known as iNOS Our immune system synthase. (Inducible)

As you research the uses of NO please be sure to identify if the research was conducted with iNOS, nNOS, or eNOS. Equine Science Solution products only use endothelial NO and are ADNO formulated.